Nephrotic Syndrome
11:28
Nephrotic Syndrome
Jan 28, 2018
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Nephrotic Syndrome Visible Features • Periorbital edema (puffy eyes, especially in the morning) • Peripheral edema (ankles, feet, legs swelling) • Ascites (abdominal swelling from fluid retention) • Foamy urine (proteinuria → frothy bubbles in urine) Pathophysiology (Inside the Body) • Kidneys: damaged glomerular basement membrane → massive proteinuria (>3.5 g/day) • Blood: hypoalbuminemia → ↓ plasma oncotic pressure → fluid shifts into tissues → edema • Liver: compensatory ↑ lipoprotein product
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