Using single-cell sequencing and spatial tools, researchers have created the most comprehensive map of the maternal–fetal interface yet.

A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

A team of researchers has constructed the most detailed single-cell map of the adult human prostate to date, cataloging more ...

Single-cell RNA transcriptomics allows researchers to broadly profile the gene expression of individual cells in a particular tissue. This technique has allowed researchers to identify new subsets of ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context. In musculoskeletal ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Scientists mapped the maternal–fetal interface revealing new cell types, genetic links, and mechanisms behind pregnancy complications.

Andreas Pfenning discusses the techniques being developed and used to study neuronal heterogeneity and the therapeutic potential of his work.