Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia. Now, the anesthetic drug may hold the keys to ...
Aberrant signaling between neurons can result in epileptic seizures, which are characterized by bursts of high activity and can be detected by an electroencephalogram or EEG. Propofol may be able to ...
The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a study led by researchers at Weill Cornell ...
Mutated variants of a particular ion channel cause difficult-to-treat epilepsy. A study published in the journal Nature now shows that a commonly used anesthetic drug, propofol, can restore the ...
Researchers from Columbia University presented novel knock-in mouse models, designed to replicate de novo sequence variations in the HCN1 voltage-gated ion channel, p.G391D and p.M153I, which are ...
Corrigendum to "Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling" [Prog. Biophys. Mol. Biol. 166 (2021) 156-172] ...
HCN channels, or hyperpolarisation‐activated cyclic nucleotide‐gated channels, are integral membrane proteins that underpin the rhythmic activity of neurons and cardiac pacemakers. These channels ...
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